[7] Guairena FC 1-2 River Plate Asuncion [2] 2021-07-25 21:15
Estádio: Estadio Parque del Guaira Round: 2
Juiz: Juan Gabriel Benitez Home Manager: Troadio Daniel Duarte Away Manager: Celso Ayala
Head to Head
| Paraguai - División Profesional | 2021/05/10 00:00 | Guairena FC v River Plate Asuncion | D | 0-0 |
| Copa Sul-Americana | 2021/04/08 22:15 | River Plate Asuncion v Guairena FC | L | 4-2 |
| Copa Sul-Americana | 2021/03/18 22:15 | Guairena FC v River Plate Asuncion | L | 1-2 |
| Paraguai - División Profesional | 2021/03/05 21:15 | River Plate Asuncion v Guairena FC | W | 0-1 |
| Paraguai - División Profesional | 2020/11/10 23:45 | River Plate Asuncion v Guairena FC | W | 1-2 |
| Paraguai - División Profesional | 2020/08/12 20:00 | River Plate Asuncion v Guairena FC | L | 2-1 |
| Paraguai - División Profesional | 2020/01/25 21:00 | Guairena FC v River Plate Asuncion | W | 2-0 |
| Paraguai - Division Intermedia | 2018/07/29 13:30 | Guairena FC v River Plate Asuncion | W | 3-0 |
Home History
| Paraguai - División Profesional | 2021/07/18 23:30 | Club Libertad v Guairena FC | D | 0-0 |
| Paraguai - División Profesional | 2021/05/28 21:45 | Club Sol de América v Guairena FC | D | 0-0 |
| Paraguai - División Profesional | 2021/05/21 23:00 | Guairena FC v Club Guaraní | D | 0-0 |
| Paraguai - División Profesional | 2021/05/16 00:00 | 12 de Octubre v Guairena FC | D | 1-1 |
| Paraguai - División Profesional | 2021/05/10 00:00 | Guairena FC v River Plate Asuncion | D | 0-0 |
| Paraguai - División Profesional | 2021/04/30 22:00 | Club Nacional v Guairena FC | W | 1-3 |
| Paraguai - División Profesional | 2021/04/25 21:45 | Guairena FC v Cerro Porteño | L | 0-1 |
| Paraguai - División Profesional | 2021/04/16 22:00 | Guairena FC v Club Olimpia | L | 1-2 |
Away History
| Paraguai - División Profesional | 2021/07/18 21:15 | Club Olimpia v River Plate Asuncion | W | 1-3 |
| Paraguai - División Profesional | 2021/05/30 21:45 | River Plate Asuncion v Club Olimpia | L | 1-2 |
| Copa Sul-Americana | 2021/05/27 00:30 | Corinthians v River Plate Asuncion | L | 4-0 |
| Paraguai - División Profesional | 2021/05/24 00:00 | Club Nacional v River Plate Asuncion | W | 0-1 |
| Copa Sul-Americana | 2021/05/18 22:15 | River Plate Asuncion v Peñarol | W | 2-1 |
| Paraguai - División Profesional | 2021/05/16 21:45 | River Plate Asuncion v Cerro Porteño | D | 1-1 |
| Copa Sul-Americana | 2021/05/14 00:30 | River Plate Asuncion v Sport Huancayo | W | 2-1 |
| Paraguai - División Profesional | 2021/05/10 00:00 | Guairena FC v River Plate Asuncion | D | 0-0 |