Estádio: Memorial Stadium (TX) Round: 1
Home Manager: Todd Whitten Away Manager: K.C. Keeler
| NCAAF | 2021/10/23 19:00 | Jacksonville State v Sam Houston State | W | 7-42 |
| NCAAF | 2021/10/09 19:00 | Lamar v Sam Houston State | W | 7-41 |
| NCAAF | 2021/10/02 21:00 | Sam Houston State v Stephen F. Austin | W | 21-20 |
| NCAAF | 2021/09/25 21:00 | Sam Houston State v Central Arkansas | W | 45-35 |
| NCAAF | 2021/09/11 23:00 | SE Missouri St v Sam Houston State | W | 14-52 |
| NCAAF | 2021/09/03 01:00 | Sam Houston State v Northern Arizona | W | 42-16 |
| NCAAF | 2021/05/16 18:00 | Sam Houston State v South Dakota State | W | 23-21 |
| NCAAF | 2021/05/08 18:30 | James Madison v Sam Houston State | W | 35-38 |
| NCAAF | 2021/10/23 23:00 | Tarleton State v Midwestern State University Mustangs | W | 17-14 |
| NCAAF | 2021/10/17 01:00 | Tarleton State v Utah Tech | W | 41-20 |
| NCAAF | 2021/10/02 19:00 | Tarleton State v Eastern Kentucky | L | 3-20 |
| NCAAF | 2021/09/25 23:00 | Tarleton State v Highlands Cowboys do Novo México | W | 40-21 |
| NCAAF | 2021/09/18 23:00 | Southern Utah v Tarleton State | L | 40-35 |
| NCAAF | 2021/09/11 23:00 | Tarleton State v Fort Lewis Skyhawks | W | 54-7 |
| NCAAF | 2021/09/04 23:00 | Tarleton State v Stephen F. Austin | L | 10-20 |
| NCAAF | 2021/04/01 23:00 | Tarleton State v East Central Tigers | L | 14-21 |