[1] Club Guaraní 2-1 River Plate Asuncion [8] 2021-11-20 22:45
Estádio: Estádio Rogelio Livieres Round: 16
Juiz: Mario Alberto Diaz De Vivar Home Manager: Fernando Jubero Away Manager: Ivan Almeida
Head to Head
| Paraguai - División Profesional | 2021/08/29 23:00 | River Plate Asuncion v Club Guaraní | W | 1-5 |
| Paraguai - División Profesional | 2021/04/12 23:00 | Club Guaraní v River Plate Asuncion | W | 2-0 |
| Paraguai - División Profesional | 2021/02/09 21:30 | River Plate Asuncion v Club Guaraní | W | 1-4 |
| Paraguai - División Profesional | 2020/11/01 21:15 | River Plate Asuncion v Club Guaraní | L | 1-0 |
| Paraguai - División Profesional | 2020/08/29 20:30 | River Plate Asuncion v Club Guaraní | L | 1-0 |
| Paraguai - División Profesional | 2020/08/05 22:30 | Club Guaraní v River Plate Asuncion | W | 3-0 |
| Paraguai - División Profesional | 2019/09/28 22:00 | River Plate Asuncion v Club Guaraní | W | 0-1 |
| Paraguai - División Profesional | 2019/07/12 23:30 | Club Guaraní v River Plate Asuncion | L | 1-3 |
Home History
| Paraguai - División Profesional | 2021/11/07 21:15 | Club Libertad v Club Guaraní | L | 2-0 |
| Paraguai - División Profesional | 2021/10/30 23:15 | Club Guaraní v Sportivo Luqueño | W | 2-1 |
| Paraguai - División Profesional | 2021/10/24 21:00 | Club Olimpia v Club Guaraní | W | 1-3 |
| Paraguai - División Profesional | 2021/10/18 21:15 | 12 de Octubre v Club Guaraní | W | 1-2 |
| Paraguai - División Profesional | 2021/10/03 21:00 | Club Guaraní v Club Nacional | D | 1-1 |
| Paraguai - División Profesional | 2021/09/27 23:30 | Club Sol de América v Club Guaraní | L | 2-1 |
| Paraguai - División Profesional | 2021/09/19 00:15 | Cerro Porteño v Club Guaraní | D | 0-0 |
| Paraguai - División Profesional | 2021/09/12 00:15 | Club Guaraní v Guairena FC | W | 3-0 |
Away History
| Paraguai - División Profesional | 2021/11/05 22:00 | River Plate Asuncion v 12 de Octubre | L | 0-2 |
| Paraguai - División Profesional | 2021/10/29 22:30 | Club Nacional v River Plate Asuncion | D | 1-1 |
| Paraguai - División Profesional | 2021/10/23 21:00 | River Plate Asuncion v Club Sol de América | L | 0-2 |
| Paraguai - División Profesional | 2021/10/18 23:30 | Cerro Porteño v River Plate Asuncion | L | 2-0 |
| Taça do Paraguai | 2021/10/06 20:30 | River Plate Asuncion v CA Tembetary | L | 0-1 |
| Paraguai - División Profesional | 2021/10/03 00:15 | River Plate Asuncion v Guairena FC | D | 1-1 |
| Paraguai - División Profesional | 2021/09/26 22:00 | River Plate Asuncion v Club Olimpia | L | 1-2 |
| Taça do Paraguai | 2021/09/21 21:00 | Deportivo Karai Chive v River Plate Asuncion | W | 2-4 |