Estádio: Estádio Dana J. Dykehouse Round: 3
Home Manager: John Stiegelmeier Away Manager: Bob Chesney
| NCAAF | 2022/12/03 17:00 | New Hampshire v Holy Cross | W | 19-35 |
| NCAAF | 2022/11/19 17:30 | Holy Cross v Georgetown | W | 47-10 |
| NCAAF | 2022/11/12 17:00 | Bryant v Holy Cross | W | 29-36 |
| NCAAF | 2022/11/05 16:00 | Lehigh v Holy Cross | W | 14-42 |
| NCAAF | 2022/10/29 17:00 | Fordham v Holy Cross | W | 52-53 |
| NCAAF | 2022/10/22 19:30 | Holy Cross v Lafayette | W | 24-21 |
| NCAAF | 2022/10/08 20:00 | Bucknell v Holy Cross | W | 0-57 |
| NCAAF | 2022/10/01 17:00 | Holy Cross v Harvard | W | 30-21 |
| NCAAF | 2022/12/03 20:00 | Delaware v South Dakota State | W | 6-42 |
| NCAAF | 2022/11/12 20:00 | Illinois State v South Dakota State | W | 7-31 |
| NCAAF | 2022/11/05 21:00 | South Dakota State v Northern Iowa | W | 31-28 |
| NCAAF | 2022/10/29 19:00 | Indiana State v South Dakota State | W | 7-49 |
| NCAAF | 2022/10/22 20:00 | South Dakota State v North Dakota | W | 49-35 |
| NCAAF | 2022/10/15 19:30 | South Dakota State v North Dakota State | W | 23-21 |
| NCAAF | 2022/10/08 19:00 | South Dakota v South Dakota State | W | 3-28 |
| NCAAF | 2022/10/01 19:00 | Western Illinois v South Dakota State | W | 10-34 |