| WTA - Florianópolis | 11/22 15:00 | 26 | [224] Despina Papamichail v Renata Zarazua [151] | 4-6,2-6 | |
| WTA - Florianópolis | 11/20 15:00 | 25 | [156] Julia Riera v Despina Papamichail [224] | 4-6,6-7 | |
| WTA - Colina | 11/15 16:20 | 26 | [131] Leolia Jeanjean v Despina Papamichail [228] | 2-6,6-4,6-2 | |
| WTA - Colina | 11/13 18:15 | 25 | [212] Solana Sierra v Despina Papamichail [228] | 3-6,2-6 | |
| ITF - W100 Les Franqueses | 10/25 11:20 | 25 | Nahia Berecoechea v Despina Papamichail | 1-6,6-2,6-2 | |
| WTA - Monastir | 10/14 10:00 | 14 | [169] Katarina Zavatska v Despina Papamichail [207] | 3-6,6-2,6-4 | |
| WTA - Tóquio | 09/28 04:25 | 26 | [13] Daria Kasatkina v Despina Papamichail [220] | 6-4,6-4 | |
| WTA - Tóquio | 09/26 05:35 | 25 | [256] Sakura Hosogi v Despina Papamichail [220] | 6-7,5-7 | |
| WTA - Tóquio | 09/26 04:50 | 25 | Natsumi Kawaguchi v Despina Papamichail | Cancelled | |
| WTA - Tóquio | 09/24 03:30 | 19 | [190] Despina Papamichail v Ellen Perez [431] | 6-4,6-3 | |
| WTA - Tóquio | 09/23 06:55 | 14 | [190] Despina Papamichail v Lidziya Marozava [61] | 6-1,6-1 | |
| WTA - Guangzhou | 09/19 06:00 | 25 | [190] Despina Papamichail v Zhuoxuan Bai [129] | 3-6,5-7 | |
| WTA - Guangzhou | 09/17 06:00 | 19 | [282] Yexin Ma v Despina Papamichail [190] | 3-6,3-6 | |
| WTA - Guangzhou | 09/16 06:20 | 14 | [93] Maia Lumsden v Despina Papamichail [190] | 6-7,1-6 | |
| WTA - Osaka | 09/10 02:55 | 19 | [191] Despina Papamichail v Arianne Hartono [206] | 1-6,5-7 | |
| WTA - Osaka | 09/09 04:25 | 14 | [191] Despina Papamichail v Naiktha Bains [295] | 6-4,6-7,6-0 | |
| Open dos EUA - Feminino | 08/25 18:40 | 15 | [193] Despina Papamichail v Vera Zvonareva [38] | 5-7,5-7 | |
| Open dos EUA - Feminino | 08/23 20:20 | 14 | [89] Jule Niemeier v Despina Papamichail [193] | 3-6,4-6 | |
| WTA - Barranquilla | 08/15 18:30 | 25 | [144] Leolia Jeanjean v Despina Papamichail [193] | 6-4,6-3 | |
| ITF - W80 Brasília | 08/11 15:35 | 27 | [202] Despina Papamichail v Laura Pigossi [144] | 2-6,4-6 | |
| ITF - W80 Brasília | 08/10 13:00 | 26 | [202] Despina Papamichail v Ana Candiotto [447] | 6-4,6-3 | |
| ITF - W80 Brasília | 08/08 14:55 | 25 | Despina Papamichail v Miriana Tona | 6-3,5-7,7-5 | |
| ITF - W60 Barcelona | 08/04 17:30 | 27 | [193] Valeria Savinykh v Despina Papamichail [213] | 3-6,7-6,6-1 | |
| ITF - W60 Barcelona | 08/03 20:00 | 26 | Emilie Lindh v Despina Papamichail | 3-6,6-3,4-6 | |
| ITF - W60 Barcelona | 08/02 17:30 | 25 | Nahia Berecoechea v Despina Papamichail | 3-6,3-6 | |
| WTA - Hamburgo | 07/23 13:30 | 19 | [169] Kaja Juvan v Despina Papamichail [201] | 6-1,6-2 | |
| WTA - Hamburgo | 07/22 15:00 | 14 | [293] Katharina Hobgarski v Despina Papamichail [201] | 4-6,3-6 | |
| WTA - Iași | 07/17 14:45 | 25 | [472] Anca Alexia Todoni v Despina Papamichail [201] | 6-4,6-4 | |
| WTA - Contrexéville | 07/10 11:40 | 25 | [188] Despina Papamichail v Anna-Lena Friedsam [87] | 3-6,4-6 | |
| Wimbledon - Feminino | 06/29 14:40 | 19 | [188] Despina Papamichail v Viktorija Golubic [138] | 2-6,6-7 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.