[1] Club América 2-1 Santos Laguna [11] 2021-10-20 00:05
Estádio: Estadio Azteca Round: 14
Juiz: Marco Antonio Ortiz Nava Home Manager: Santiago Solari Away Manager: Guillermo Almada
Head to Head
| Europa - Amigáveis | 2021/07/05 00:30 | Club América v Santos Laguna | W | 1-0 |
| México - Liga MX | 2021/02/01 01:06 | Santos Laguna v Club América | D | 1-1 |
| México - Liga MX | 2020/08/14 02:00 | Club América v Santos Laguna | W | 3-1 |
| México - Liga MX | 2019/11/03 01:00 | Club América v Santos Laguna | L | 1-2 |
| México - Liga MX | 2019/04/28 00:00 | Club América v Santos Laguna | W | 1-0 |
| Mundo - Amigáveis de Clubes | 2018/12/29 22:30 | Club América v Santos Laguna | D | 1-1 |
| México - Liga MX | 2018/11/12 00:00 | Santos Laguna v Club América | D | 1-1 |
| México - Liga MX | 2018/05/14 00:00 | Club América v Santos Laguna | D | 2-2 |
Home History
| México - Liga MX | 2021/10/17 00:00 | Atlético San Luís v Club América | W | 0-1 |
| Mundo - Amigáveis de Clubes | 2021/10/09 01:30 | Club América v Pumas | L | 0-1 |
| México - Liga MX | 2021/10/03 22:00 | Club América v Pumas | W | 2-0 |
| México - Liga MX | 2021/09/29 02:05 | Pachuca v Club América | D | 1-1 |
| México - Liga MX | 2021/09/26 02:00 | Club América v Chivas Guadalajara | D | 0-0 |
| México - Liga MX | 2021/09/19 00:00 | Toluca v Club América | L | 3-1 |
| CONCACAF - Taça dos Campeões | 2021/09/16 01:00 | Philadelphia Union v Club América | W | 0-2 |
| México - Liga MX | 2021/09/12 02:00 | Club América v Mazatlán FC | W | 2-0 |
Away History
| México - Liga MX | 2021/10/17 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| México - Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlán FC | W | 1-0 |
| México - Liga MX | 2021/09/27 00:06 | Santos Laguna v Monterrey | L | 1-2 |
| México - Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |
| México - Liga MX | 2021/09/11 02:06 | Tijuana v Santos Laguna | L | 2-1 |
| México - Liga MX | 2021/08/29 23:00 | Santos Laguna v Juárez FC | W | 2-0 |
| México - Liga MX | 2021/08/22 00:00 | Club León v Santos Laguna | D | 1-1 |